Defective immune system caused by a genetic defect associated with severe COVID-19

Why do some people get light COVID-19 when others get very sick or even die?

The new coronavirus SARS-CoV-2 is the source of COVID-19, a disease that destroyed the planet in 2020 and has so far caused more than 500 million infections and 5 million deaths.

Most patients with SARS-CoV-2 infection do not have severe symptoms. Nonetheless, male sex, aging, pre-existing heart disease, hypertension, diabetes, cancer, and obesity are all recognized as serious and even fatal risk factors for COVID-19.

However, given that many older people have been documented with a mild or asymptomatic disease and some younger, seemingly healthy individuals may suffer from serious illness or mortality, these traits are responsible for a small fraction of the risk.

In contrast to the latest global epidemic caused by the human immunodeficiency virus (HIV), humans do not exhibit species-level vulnerabilities to SARS-CoV-2, but some individuals exhibit a risk that is significantly higher than the risk experienced by the general population. .

According to Australian researchers, this may be due to an unknown immunodeficiency (defective immune system) in people who become seriously ill.

They discovered genetic defects that weakened the immunity of lethal COVID-19 patients and estimated that these mutations could occur in 3% to 5% of all serious COVID-19 cases in people under 70 years of age.

They further claimed that immune-related antibodies that prevent the body from properly fighting COVID-19 were detected in about 20% of severe COVID-19 cases in people under 70 years of age, as well as 20% of patients who died. . The disease.

They suggest that immunodeficiency-targeted therapies may be effective in preventing COVID-19 from becoming serious in people with these problems.

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