The diameter of the thoracic artery is a biomarker for heart attack and other adverse cardiovascular events in women and men, according to a new study published in the journal Radiology.
Aorta is a large artery that carries oxygenated blood to the heart and other parts of the body. The part that goes through the chest, known as the thoracic aorta, is divided into an ascending aorta that rises from the left ventricle of the heart and a descending aorta behind the chest.
Chest aorta grows with age, but changes in vessel size and structure, a phenomenon known as vascular remodeling, have a systemic nature that involves basic measures of hemodynamic-cardiovascular function and blood circulation এবং and biological processes that are cardiovascular. Associated with
“Thoracic aorta enlargement is a frequent finding in clinical practice, but there is some long-term data regarding its long-term prognosis for the outcome of large cardiovascular disease at the population level,” said Maryam Kavousi MD, PhD, senior author of the study. Department of Epidemiology at Erasmus MC, Rotterdam, University Medical Center Rotterdam in the Netherlands.
Of the 2,178 participants in the population-based Rotterdam study, Dr. Cavusi and colleagues evaluated these organizations. Participants underwent multi-detector CT scans between 2003 and 2006 and were followed for an average of nine years. Chest aorta diameter was indicated for body mass index (BMI).
Larger BMI-indexed ascending and descending thoracic aortic diameters were significantly associated with increased risk of adverse cardiovascular outcomes, such as stroke and death, in both men and women.
“Our results suggest that imaging-based assessment of the diameter of the thoracic aorta may be considered a risk indicator for future cardiovascular disease,” said Dr. Kavousi.
Among women, a larger ascending aortic diameter was associated with a 33% higher risk of cardiovascular death. Reconstruction of the aging aorta seems to be different with the rapid deterioration of women between men and women.
“Aging can adversely affect the health and structure of the aorta in women more than in men,” said Dr. Cavusi.
The results of the study suggest that cardiovascular risk assessment associated with thoracic aortic size in asymptomatic women and men may lead to effective, gender-specific prevention strategies.
“Since aortic diameter is significantly related to body size, the use of indexed aortic diameter for body measurements may improve its prognostic value for cardiovascular outcomes,” said Dr. Kavousi.
Assessment of thoracic aorta size could easily be added to existing screening methods, the researchers said. Cardiac CT scans placed in the study are already commonly used to assess coronary calcium. Thoracic aortic diameter can also be measured regularly, for example as part of CT-based lung cancer screening.
The current study was based on a single city-based assessment of the thoracic aorta in a large group of participants in the general population, followed for nine years for cardiovascular outcomes and mortality. Researchers recently repeated a thoracic aorta CT-based assessment among these participants after the middle of 14 years.
“It provides an exciting and unique opportunity to study the sex-specific risk profile and the types of growths in the thoracic aorta of the general population,” said Dr. Kavousi.
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